Endocrine Abstracts

We have used an androgen receptor knockout (ARKO) mouse model with an in-frame deletion of the 2nd zinc finger of the DNA binding domain, which abolishes the genomic actions of the AR to investigate androgen regulation of fat mass. At 12 weeks of age, ARKO males have increased adiposity compared to wildtype (WT) males, with subcutaneous fat mass increased by 75% (P<0.001, n≥17/group) and infrarenal fat mass increased by 36% (P<0.05, n&...

Sex steroids have complex effects: testosterone predominantly regulates trabecular and estradiol, cortical bone1. Studies in transgender individuals use insensitive technology and report conflicting effects2. We hypothesized estradiol therapy will increase cortical volumetric bone mineral density (vBMD) in male-to-female (MtF) individuals and testosterone therapy will increase trabecular vBMD in female-to-male (FtM) individuals.Aims...

Objective: To determine the prevalence and characteristics of psychiatry inpatients with type 2 diabetes and pre-diabetes, compared to psychiatry inpatients without diabetes.Research design and methods: Inpatients aged >30 years at the Austin psychiatry unit (February 2014–April 2015) had HbA1c measurements as part of the Diabetes Discovery Initiative. Patients were divided into three groups – diabetes (HbA1c ≥6.5%, 48 mmol/mol), pre-...

Background: Androgen deprivation therapy (ADT) for prostate cancer (PCa) leads to a global loss of lean mass. ADT leads to sexual dysfunction and a selective loss of leg muscle function, however individual muscle volumes have never been evaluated. We aimed to assess in men undergoing ADT, the muscle volumes of levator ani, which in mice is androgen-responsive, and of lower-limb muscles.Methods: We conducted a prospective case-control study involving 34 m...

Introduction: Contrast-induced nephropathy (CIN) is an important cause of acute kidney injury (AKI) in inpatients. However, the prevalence and predisposing factors for CIN remain poorly documented. The aim of this study was to investigate the association between CIN, kidney function and diabetic status in inpatients.Methods: We identified inpatients who received IV contrast prior to a computed tomography (CT) scan between July 2012 to March 2018 at Austi...